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The leading-order low-energy constant in mixed-action chiral perturbation theory is calculated using -flavor gauge ensembles with HISQ fermions and a tadpole-improved Symanzik gauge action at four lattice spacings fm. By comparing our results to those from different actions and a -flavor case, We find that the fermion action has the dominant impact, the gauge action has a secondary but measurable effect, and the contribution from charm quark loops is negligible within our current uncertainties.

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