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We extend the well-known Serrin’s blowup criterion for the three-dimensional (3D) incompressible Navier-Stokes equations to the 3D viscous compressible cases. It is shown that for the Cauchy problem of the 3D compressible Navier-Stokes system in the whole space, the strong or smooth solution exists globally if the velocity satisfies the Serrin’s condition and either the supernorm of the density or the -norm of the divergence of the velocity is bounded. Furthermore, in the case that either the shear viscosity coefficient is suitably large or there is no vacuum, the Serrin’s condition on the velocity can be removed in this criteria.

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