We study zero-divisors in the -dimensional sedenion algebra from the viewpoint of the determinant of left multiplication. We show that this determinant admits a canonical factorization into the square of a quartic polynomial, obtained via a -invariant reduction to a quaternionic normal form and an explicit block computation. The quartic factor recovers the classical characterization of left zero-divisors in terms of the imaginary components. After normalization, the resulting zero-divisor manifold is identified with the Stiefel manifold . We also analyze a -dimensional purely imaginary slice, on which the quartic reduces to a simple quadratic form. This yields a concrete geometric model of the zero-divisor locus as a quadratic cone in the slice.

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