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High-harmonic generation from hydrogenlike muonic atoms exposed to ultraintense high-frequency laser fields is calculated. Systems of low nuclear charge number Z are considered where a nonrelativistic description applies. By comparing the radiative response for different isotopes we demonstrate characteristic signatures of the finite nuclear mass and size in the harmonic spectra. In particular, for Z>1, an effective muon charge appears in the Schr"odinger equation for the relative particle motion, which influences the position of the harmonic cutoff. Cutoff energies in the MeV domain can be achieved, offering prospects for the generation of ultrashort coherent gamma-ray pulses.

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