We have measured the inclusive semileptonic branching fractions of , , and mesons. For these measurements, we have used the full CLEO-c open-charm data samples, 818 pb at GeV, giving and events, and 602 pb at $E_ = 4.170D^{\ast \pm}_s D^\mp_s(D^0 \to X e^+ \nu_e) = (6.46 \pm 0.09 \pm 0.11)(D^+ \to X e^+ \nu_e) = (16.13 \pm 0.10 \pm 0.29)(D^+_s \to X e^+ \nu_e) = (6.52 \pm 0.39 \pm 0.15)$%, where the first uncertainties are statistical and the second are systematic. From these and lifetimes obtained elsewhere, we obtain the ratios of semileptonic decay widths $\Gamma (D^+ \to X e^+ \nu_e) / \Gamma (D^0 \to X e^+ \nu_e) = 0.985 \pm 0.015 \pm 0.024\Gamma (D^+_s \to X e^+ \nu_e) / \Gamma (D^0 \to X e^+ \nu_e) = 0.828 \pm 0.051 \pm 0.025$. The ratio of and is consistent with the isospin symmetry prediction of unity, and the ratio of and differs from unity, as expected.

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