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The mass splittings in the pseudoscalar mesons are studied by combining 2+1 flavor domain wall fermion gauge configurations, generated by the RBC/UKQCD collaborations, and quenched, non-compact, lattice QED configurations. We extract the QED low energy constants in SU(3) partially quenched chiral perturbation theory, up to next-to-leading order, and determine the non-degenerate u, d and s quark masses. Systematic uncertainties due to chiral extrapolations are discussed. The chiral symmetry breaking of domain wall fermions on the lattice and its effect in partially quenched chiral perturbation theory, including QED effects, is also investigated.

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