Prescribing curvature equations are fully nonlinear generalizations of the prescribing Gaussian or scalar curvature equations. Given a positive function to be prescribed on the 4-dimensional round sphere. We obtain asymptotic profile analysis for potentially blowing up solutions to the curvature equation with the given ; and rule out the possibility of blowing up solutions when satisfies a non-degeneracy condition. We also prove uniform a priori estimates for solutions to a family of curvature equations deforming to a positive constant under the same non-degeneracy condition on , and prove the existence of a solution using degree argument to this deformation involving fully nonlinear elliptic operators under an additional, natural degree condition on a finite dimensional map associated with .

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