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We propose a quantum-enhanced picostrain sensor that achieves Heisenberg-limited strain sensing using superconducting qubits. A strain-sensitive qubit s Hamiltonian is coupled to the momentum quadrature of a microwave resonator, transducing mechanical strain into amplified spatial displacements of the resonator s phase space. Using homodyne detection of the resonator field and multipartite entanglement of N qubits, the protocol achieves a strain sensitivity (picostrain), two orders of magnitude better than classical sensors. The scheme integrates natively with superconducting processors, enabling in-situ diagnostic and nanoscale material characterization.

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