OPERA (\emph{O}scillation \emph{P}roject with \emph{E}mulsion t\emph{R}acking \emph{A}pparatus) is a long-baseline neutrino experiment, designed to provide the first direct proof of oscillation in the atmospheric sector using the \emph{C}ERN \emph{N}eutrinos to \emph{G}ran \emph{S}asso (CNGS) beam. The detector, consisting of a modular target made of lead - nuclear emulsion units complemented by electronic trackers and muon spectrometers, has been conceived to select charged current interactions, among all neutrino flavour events, through the observation of the outcoming tau leptons and subsequent decays. In this paper, the detector, the event analysis chain and the preliminary results from the first OPERA physics run are reported.

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