We study the doping evolution of the electronic structure in the normal phase of high- cuprates. Electronic structure and Fermi surface of cuprates with single CuO layer in the unit cell like LaSrCuO have been calculated by the LDA+GTB method in the regime of strong electron correlations (SEC) and compared to ARPES and quantum oscillations data. We have found two critical concentrations, and , where the Fermi surface topology changes. Following I.M. Lifshitz ideas of the quantum phase transitions (QPT) of the 2.5-order we discuss the concentration dependence of the low temperature thermodynamics. The behavior of the electronic specific heat is similar to the Loram and Cooper experimental data in the vicinity of .

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