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We study tilting for a class of Calabi-Yau algebras associated to helices on Fano varieties. We do this by relating the tilting operation to mutations of exceptional collections. For helices on del Pezzo surfaces the algebras are of dimension three, and using an argument of Herzog, together with results of Kuleshov and Orlov, we obtain a complete description of the tilting process in terms of quiver mutations.

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