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We present a mechanism able to generate the perturbatively absent up/down quark Yukawa couplings of SU(5)/flipped SU(5) GUTS in Type II orientifold compactifications with D-branes. The mechanism works when there are Sp(N) gauge groups involved. The 's get charged under the Sp(N) gauge groups and the generation of quark masses proceeds via the generation of the fermionic Sp(N) singlet condensate in the term $(1/{M_s^5}) {\bf 10} \cdot {\bf 10} \cdot < {\bf {\bar 5} \cdot {\bar 5} \cdot {\bar 5} \cdot {\bar 5}}>$. Also non-chiral states charged under Sp gauge groups may become constrained by the requirement of Sp’s becoming strongly coupled.

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