We consider constraints from flavor physics on two-Higgs-doublet models (2HDM) with general, flavor-diagonal, Yukawa couplings. Analyzing the charged Higgs contribution to different observables, we find that transitions and restrict the coupling of the top quark (corresponding to in models with a symmetry) to for GeV. Stringent constraints from meson decays are obtained also on the other third generation couplings and , but with stronger dependence on . For the second generation, we obtain constraints on combinations of , , and from leptonic and decays. The limits on the general couplings are translated to the common 2HDM types I – IV with a symmetry, and presented on the plane. The flavor constraints are most excluding in the type II model which lacks a decoupling limit in . We obtain a lower limit GeV in models of type II and III, while no lower bound on is found for types I and IV.

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