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A reliable determination of the Cabibbo-Kobayashi-Maskawa matrix element is mandatory for precision flavor physics and for the search for CP violating phases from new, heavy particles. In this article, we review the theory of the determination of from inclusive semileptonic decays. We discuss the available measurements of the semileptonic branching fraction and other inclusive observables in B decays relevant to the determination of . Finally, we perform a global fit to extract and the -quark mass .

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