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We study the single transverse-spin asymmetry for open charm production in the semi-inclusive lepton-hadron deep inelastic scattering (SIDIS) and collision. Within collinear factorization approach, we find that the asymmetry is sensitive to the twist-3 trigluon correlation functions in the proton. With a simple model for the trigluon correlation functions, we estimate the asymmetry in SIDIS for both COMPASS and eRHIC kinematics, as well as in collision at RHIC energy. We discuss the possibilities of extracting the trigluon correlation functions in these experiments.

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