Gap solitons near a band edge of a spatially periodic nonlinear PDE can be formally approximated by solutions of Coupled Mode Equations (CMEs). Here we study this approximation for the case of the 2D Periodic Nonlinear Schr"{o}dinger / Gross-Pitaevskii Equation with a non-separable potential of finite contrast. We show that unlike in the case of separable potentials [T. Dohnal, D. Pelinovsky, and G. Schneider, J. Nonlin. Sci. {\bf 19}, 95–131 (2009)] the CME derivation has to be carried out in Bloch rather than physical coordinates. Using the Lyapunov-Schmidt reduction we then give a rigorous justification of the CMEs as an asymptotic model for reversible non-degenerate gap solitons and even potentials and provide estimates for this approximation. The results are confirmed by numerical examples including some new families of CMEs and gap solitons absent for separable potentials.

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