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We consider the contributions to from fourth generation neutral and charged leptons, and , at the one-loop level. Diagramatically, there are two types of contributions: boson-boson-, and --boson in the loop diagram. In general, the effect from is suppressed by off-diagonal PMNS matrix element , from the Standard Model to the Two-Higgs Doublet Models. With contribution from , we consider flavor changing neutral couplings.

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