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Temperature effect on quantum tunneling in a Cooper-pair-box coupled to a quantum oscillator is studied by both numerical and analytical calculations. It is found that, in strong coupling regions, coherent tunneling of a Cooper-pair-box can be destroyed by its coupling to a quantum oscillator and the tunneling becomes thermally activated as the temperature rises, leading to failure of the Cooper-pair-box. The transition temperature between the coherent tunneling and thermo-activated hopping is determined and physics analysis based on small polaron theory is also provided.

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