In this paper, the holographic dark energy model is considered in Brans-Dicke theory where the holographic dark energy density $\rho_{\Lambda} =3c^2 M^{2}{pl} L^{-2}\rho{h}=3c^2 \Phi(t)L^{-2}\Phi(t)=\frac{1}{8\pi G}$ is a time variable Newton constant. With this replacement, it is found that no accelerated expansion universe will be achieved when the Hubble horizon is taken as the role of IR cut-off. When the event horizon is adopted as the IR cut-off, an accelerated expansion universe is obtained. In this case, the equation of state of holographic dark energy takes a modified form . In the limit $\alpha\to 0$, the ‘standard’ holographic dark energy is recovered. In the holographic dark energy dominated epoch, power-law and de Sitter time-space solutions are obtained.

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