Sufficient conditions for the similarity of the operator $A := 1/r(x) (-d^2/dx^2 +q(x))r(x)=(\sgn x)|r(x)|$ are obtained. These conditions are formulated in terms of Titchmarsh-Weyl -coefficients. Sufficient conditions for the regularity of the critical points 0 and of -nonnegative Sturm-Liouville operators are also obtained. This result is exploited to prove the regularity of 0 for various classes of Sturm-Liouville operators. This implies the similarity of the considered operators to self-adjoint ones. In particular, in the case and , we prove that is similar to a self-adjoint operator if and only if is -nonnegative. The latter condition on is sharp, i.e., we construct $q\in \cap_{\gamma <1} L^1(R, (1+|x|)^\gamma dx)AJ$-nonnegative with the singular critical point 0. Hence is not similar to a self-adjoint operator. For periodic and infinite-zone potentials, we show that -positivity is sufficient for the similarity of to a self-adjoint operator. In the case , we prove the regularity of the critical point 0 for a wide class of weights . This yields new results for “forward-backward” diffusion equations.

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