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The baryon asymmetry of the Universe requires CP violation, but the Standard Model falls short by a factor of or more. Starting from a clue at the factories, we point out that the large Yukawa couplings of the sequential fourth generation and quarks can provide enhancement by a factor of over , making the 2-3-4 generation quark sector a viable source of CP violation for the baryon asymmetry of the Universe. With recent hints of large in - mixing from the Tevatron, the ultimate test would be to discover the and quarks at the Large Hadron Collider.

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