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We consider a leptophobic Z^\prime scenario in a flipped SU(5) grand unified theory obtained from heterotic string theory. We show that the allowed Z^\prime mass, flavor conserving and flavor changing couplings of the Z^\prime to the down-type quarks are strongly constrained by the mass difference in B_s-\bar{B}_s system and the four branching ratios of B -> \pi K decays. It is shown that even under these constraints large deviations in direct and/or indirect CP asymmetries of B \to \pi K decays from the SM expectations are allowed. Especially it is possible to accommodate the apparent puzzling data in B -> \pi K CP asymmetries.

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