Consider a system of bosons in three dimensions interacting via a repulsive short range pair potential , where $\bx=(x_1, >…, x_N)H_N$ denote the Hamiltonian of the system and let be the solution to the Schr"odinger equation. Suppose that the initial data satisfies the energy condition and that the one-particle density matrix converges to a projection as . Then, we prove that the -particle density matrices of factorize in the limit . Moreover, the one particle orbital wave function solves the time-dependent Gross-Pitaevskii equation, a cubic non-linear Schr"odinger equation with the coupling constant proportional to the scattering length of the potential . In \cite{ESY}, we proved the same statement under the condition that the interaction potential is sufficiently small; in the present work we develop a new approach that requires no restriction on the size of the potential.

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