Assume that there is a set of monic polynomials satisfying the second-order difference equation where $z(s), A(s), B(s), C(s)sN$ may be either finite or infinite. The irreducibility condition is assumed for all admissible values of . In the finite case we assume that there are distinct grid points such that $z(i) \ne z(j), : i \ne jN=\inftyz(s)$ has infinitely many different values for different values of . In both finite and infinite cases we assume also that the problem is non-degenerate, i.e. $\lambda_n \ne \lambda_m, n \ne mz(s)$ is at most quadratic or q-quadratic in ; (ii) corresponding polynomials are at most the Askey-Wilson polynomials corresponding to the grid . This result can be considered as generalizing of the Bochner theorem (characterizing the ordinary classical polynomials) to generic case of arbitrary difference operator on arbitrary grids.

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