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We estimate the running coupling constant of the strong interactions within the nonperturbative framework of lattice QCD in Landau gauge. Our calculation is based on the ghost-gluon vertex which in the particular case of Landau gauge allows for a definition of alpha(s) in a MOM scheme solely in terms of the gluon and ghost dressing functions. As a first step we investigate the zero and two-flavour case and report here on preliminary results.

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