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We derive new consistency conditions for string compactifications with generic fluxes (RR, NSNS, geometrical) and localized sources (D-branes, NS-branes, KK-monopoles). The constraints are all related by string dualities and share a common origin in M-theory. We also find new sources of instabilities. We discuss the importance of these conditions for the consistency of the effective action and for the study of interpolating solutions between vacua.

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