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We present a model for inclusive electron and neutrino scattering off nuclei paying special attention to the influence of in-medium effects on the quasi-elastic scattering and pion-production mechanisms. Our results for electron scattering off Oxygen are compared to experimental data at beam energies ranging from 0.7-1.5 GeV. The good description of electron scattering serves as a benchmark for neutrino scattering.

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