We present a fully back-reacted Einstein–Maxwell–Dilaton–flavor model with dynamical light and strange sectors, calibrated to lattice QCD using a machine-learning–assisted spectral method. The model reproduces the 2+1-flavor equation of state and chiral dynamics with quantitative accuracy, and maps the Columbia plot with a tri-critical point at and a critical mass , consistent with lattice results. At finite density, it yields a crossover-to-first-order transition and predicts a critical endpoint at and , within the reach of heavy-ion experiments. These findings establish a unified holographic framework for the QCD phase structure across quark masses and baryon density, providing the first consistent and quantitative description of both deconfinement and chiral transitions within a single holographic model.

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