We explore the extent to which a variant of a celebrated formula due to Jost and Pais, which reduces the Fredholm perturbation determinant associated with the Schr"odinger operator on a half-line to a simple Wronski determinant of appropriate distributional solutions of the underlying Schr"odinger equation, generalizes to higher dimensions. In this multi-dimensional extension the half-line is replaced by an open set , , $n\geq 2\Omega\partial\Omega$ satisfying certain regularity conditions. Our variant involves ratios of perturbation determinants corresponding to Dirichlet and Neumann boundary conditions on and invokes the corresponding Dirichlet-to-Neumann map. As a result, we succeed in reducing a certain ratio of modified Fredholm perturbation determinants associated with operators in , , to modified Fredholm determinants associated with operators in , . Applications involving the Birman-Schwinger principle and eigenvalue counting functions are discussed.

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