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The blow-up in finite time for the solutions to the initial-boundary value problem associated to the multi-dimensional quantum hydrodynamic model in a bounded domain is proved. The model consists on conservation of mass equation and a momentum balance equation equivalent to a compressible Euler equations corrected by a dispersion term of the third order in the momentum balance. The proof is based on a-priori estimates for the energy functional for a new observable constructed with an auxiliary function, and it is shown that, under suitable boundary conditions and assumptions on the initial data, the solution blows up after a finite time.

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