EP J062132.0+623837 is a new X-ray source identified in 14-day binned survey data from the Wide-field X-ray Telescope aboard the Einstein Probe (EP). Subsequent X-ray observations with the Follow-up X-ray Telescope (FXT) on board EP localized the source to the central region of the galaxy 2MASX J06213207+6238390 at . Here, we present a comprehensive analysis of the multi-wavelength data for this object. During the FXT and Swift/XRT follow-up, the source remained X-ray active, with observed luminosities of erg s, and its X-ray spectra were well described by power-law models with photon indices of . The optical spectrum of the host galaxy clearly reveals a broad-line active galactic nucleus (AGN) exhibiting significantly enhanced broad Balmer emission lines compared to an archival spectrum obtained four years earlier, thereby marking a changing-look transition from Type 1.8 to Type 1.5. Furthermore, long-term optical and mid-infrared light curves indicate that the nucleus underwent dramatic brightening around 2010 and has since shown substantial variability. Given the spatial coincidence and multi-wavelength behavior, we identify EP J062132.0+623837 as a changing-look AGN, initially detected by EP and subsequently confirmed to exhibit large-amplitude variability across multiple bands. This case study demonstrates the great potential of wide-field time-domain X-ray surveys for discovering changing-look AGNs, paving a new avenue for their systematic identification as a powerful complement to ongoing optical surveys.

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