We present an updated analysis of non-standard neutrino self-interactions, where the interaction is effectively mediated by a heavy particle, using the latest available data from DESI and the CMB. The considered data include combinations of DESI DR1 full-shape galaxy clustering (FS), BAO distance measurements, Lyman- 1D power spectra (Ly-), and a combined CMB likelihood (CMB-SPA) using data from Planck, ACT, and SPT. First, we probe two DESI DR1-only datasets, where the effective interaction parameter is multimodal in the profile likelihood, leading us to analyze two different regimes: moderately interacting (MI) and strongly interacting (SI) neutrinos. With FS+BAO, the evidence disfavors the SI mode, a trend that becomes slightly stronger with the inclusion of Ly-. However, in the latter dataset, the MI region shows a bimodality in which the intermediate mode is very sharp and peaks around ; interestingly, this mode is not penalized versus the weaker standard-like mode. Furthermore, we test CMB and DESI joint data and show that the SI mode is more disfavored by CMB-SPA than by Planck-only data. In particular, the evidence against this mode becomes the strongest thus far (with odds of 5:100000) in the FS+BAO+CMB-SPA combination.

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