We address the question of global in time existence for the semilinear parabolic equation \begin{equation*} \left{ \begin{array}{rcl} \partial_t u-Δu&=&|u|^{b-1}u \quad {\rm ~in~} ^n\times (0,\infty),\ u(\cdot,0)&=& u_0 \quad {\rm ~in~} ^n, \end{array} \right. \end{equation*} where . We found a space of initial data that guarantees the existence of a global in time solution whenever the norm of the initial datum in is small. The space is optimal in the sense that if is a nonnegative distribution and the equation admits a nonnegative solution , then . Moreover, our result contains all of the known results in the literature. In particular, it implies that global in time existence does hold for end-point Besov and Triebel-Lizorkin spaces, which resolves an open problem posed by L. Brandolese and F. Cortez (J. Funct. Anal. (2019), 2589-2604).

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