We present a lattice-QCD calculation of the leading-order hadronic-vacuum-polarization (HVP) contribution to the anomalous magnetic moment of the muon in isospin-symmetric QCD. We employ the gauge configurations generated by the Extended Twisted Mass Collaboration (ETMC) with flavors of Wilson-clover twisted-mass quarks at four lattice spacings and at values of the quark-mass parameters matching the definition of isospin-symmetric QCD given in the FLAG review 2024 and in the 2025 edition of the Muon Theory Initiative White Paper (WP25). After retuning the simulation parameters to precisely match these two definitions of isospin-symmetric QCD, and after carrying out an extrapolation to the continuum limit based on the data at lattice spacings and ~fm, and spatial lattice sizes up to ~fm, we obtain and . Our results, which have a relative uncertainty of about , agree well with the corresponding determinations by other lattice groups. After adding to our determination of the leading isospin-breaking corrections provided in the WP25, namely , we obtain for the full HVP the value . This result translates into a Standard Model prediction for the muon anomalous magnetic moment that is fully consistent with the latest result by the Fermilab Muon experiment and strengthens the tension between lattice QCD and data-driven (pre-CMD3) dispersive determinations.

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