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We investigate the three-dimensional barotropic compressible Navier–Stokes equations involving vacuum in a bounded domain with Navier-slip boundary conditions. It is shown that such a model admits a unique global strong solution provided the gradient of the initial velocity and the initial pressure deviation are suitably small in . In particular, Our result provides a new analytical framework for the global well-posedness theory of the compressible Navier–Stokes equations.

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