The detection and quantification of quantum entanglement are central problems in quantum information science. Based on the realignment of density matrices and the vectorization of reduced density matrices, we construct a family of enhanced separability criteria for bipartite and multipartite quantum systems. Our criteria recover the previously proposed realignment-based criteria as special cases and detect more entanglement than the earlier ones. Moreover, we derive tighter lower bounds for the concurrence and the convex-roof extended negativity, criteria for detecting the genuine tripartite entanglement, and lower bounds on genuine-multipartite-entanglement concurrence. The advantages of our results are demonstrated with detailed examples.

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