We develop a homotopical framework for understanding the space of quantum spin systems based on topological -nets, which assign associative unital algebras to local regions in an -dimensional space in a manner that captures the locality structure of the underlying lattice theories. The net-theoretic perspective admits a natural categorification, in which the category of topological -nets carries the structure of a higher Morita category. Moreover, the nets of greatest physical interest form a Karoubi-complete subcategory that shares many of the characteristic structural features of the category of finite TQFTs. Our main result identifies the group of locality-preserving symmetries of (3+1)-dimensional quantum spin systems (i.e. quantum cellular automata modulo stabilization, finite-depth quantum circuits, and translations) with the full Witt group of nondegenerate braided fusion categories, thereby answering a question posed by Haah.

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