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In this note we show that if a contractible Stein manifold with the density property admits a proper holomorphic embedding into , then is biholomorphic to with . Combined with an announced result of Auroux, Bai and Pomerleano, this shows that for some there is a complex affine variety such that is biholomorphic to and is not biholomorphic to . This settles the Holomorphic Cancellation Problem in the negative.

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