In this paper, we rigorously justify the low Mach number limit of the full compressible Navier-Stokes equations in a three-dimensional smooth bounded domain, subject to the no-slip boundary condition for the velocity and well-prepared initial data. In the presence of heat conduction and large temperature variations, we establish the uniform estimates for strong solutions on a time interval independent of the Mach number by constructing an energy functional in a Sobolev framework. The no-slip boundary condition cannot provide the vorticity boundary relation used in the slip-boundary setting. A key ingredient is to employ a divergence-free Stokes lifting of the boundary trace of the time derivative of modified velocity to define a test function vanishing on the boundary.

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