We discuss three aspects of the ongoing efforts of the CTEQ–TEA group toward global parton distribution function (PDF) analyses beyond NNLO accuracy in QCD. First, we present a realization of the SACOT- general-mass variable flavor number scheme for deep-inelastic scattering (DIS) at the partial next-to-next-to-next-to-leading order (pNLO) in QCD. We numerically illustrate how this SACOT- theory prediction captures the dependence of DIS structure functions on masses of heavy quarks with inclusion of the available contributions. Second, we discuss a preliminary pNLO CT25 fit that implements such contributions. Third, we extend the Candia algorithm for solving DGLAP evolution equations for unpolarized parton distribution functions (PDFs) in space to NLO in QCD. The algorithm is based on logarithmic expansions of the solution and can be extended to all orders in QCD. An expansion equivalent to the exact DGLAP solution at NLO is presented in the non-singlet sector. We show results for approximate NLO PDFs evolved using the most recent approximations to the 4-loop splitting functions in QCD.

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