We investigate the Casimir effect of a massive, self-interacting real scalar field with quartic coupling in a -dimensional Hořava-Lifshitz-type theory, subject to rough boundaries obeying Dirichlet boundary conditions. Using the effective action and generalized -function approach, we derive the renormalized effective potential, incorporating anisotropic scaling, boundary roughness, and temperature in the low-temperature regime. We determine the topological mass at one-loop order and the Casimir energy up to two loops. In the massless limit, the topological mass and the two-loop Casimir contribution exhibit infrared divergences for odd values , associated with the absence of an intrinsic mass scale, while the one-loop Casimir energy remains finite. For , the standard relativistic Dirichlet result is recovered in the zero-temperature and vanishing-roughness limits.

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