We investigate the potential of future observations of the Dark Ages 21 cm power spectrum to probe the scale dependence of the primordial power spectrum and distinguish between inflationary models. We find that the Dark Ages 21 cm power spectrum can serve as a powerful probe of inflationary physics on scales beyond the reach of current CMB observations. While models predicting nearly identical running spectral indices may remain difficult to distinguish even with future 21 cm observations, models with unconventional scale dependence can be stringently tested. We further show that combining 21 cm observations with CMB data can significantly improve the constraints, even for a moderate observational configuration. We examine the impact of the choice of pivot scale on the resulting constraints.

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