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We prove finite time blow-up from smooth, radial, compactly supported initial data for the energy supercritical defocusing nonlinear Schrödinger equation in , for . The solutions are asymptotically self-similar, their norm grows at the scaling rate , and their critical Sobolev norm diverges. This closes the conjecture of Bourgain \cite{Bourgain2000} on global well-posedness and scattering for the defocusing energy supercritical equation in dimensions three and four. The proof relies on a shooting argument and is computer-assisted.

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