By using spherical harmonicas decomposition and Gaussian-type Poincaré inequalities, we establish several sharp stability estimates for the following second-order weighted Heisenberg Uncertainty Principle \begin{equation*} \int_{^N} !\frac{|Δu|^2} {|x|^{2α}} x \int_{^N} |x|^{2α+2}|\nabla u|^2x \geq \frac{(N+4α+2)^2}{4} \left(\int_{^N} |\nabla u|^2 x\right)^2, \end{equation*} and \begin{equation*} \int_{^{N}} \frac{|Δu|^{2}} {|x|^{2α}} x +\int_{^{N}} \left|x\right|^{2α+2} |\nabla u|^{2}x \ge\left(N+4α+2\right) \int_{^{N}} |\nabla u|^{2}x. \end{equation*} We also provide the explicit value and the necessary and sufficient condition for attainability of the sharp stability constants. Moreover, when , our results reduce into those of [\emph{Calc. Var. Partial Differential Equations} (2025), Paper No. 129], [\emph{J. Funct. Anal.} (2026), Paper No. 111321] and [arXiv:2510.00453].

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