We show that persistence-based topology of the 21 cm forest encodes information about Cosmic Dawn that is complementary to traditional amplitude- or correlation-based statistics. Applying topological data analysis to simulated one-dimensional forest spectra over a grid of X-ray heating efficiencies and warm-dark-matter masses (which set the free-streaming scale), we construct persistence diagrams and Betti-0 curves that track the birth-merger hierarchy of absorption troughs under sublevel filtrations. From these summaries we define three interpretable descriptors: the trough line density , the total squared persistence , and the Betti-curve asymmetry . In a Fisher forecast around a fiducial WDM model, and provide strong local leverage on the heating axis, while retains appreciable sensitivity to the free-streaming scale and supplies an inclined constraint direction that reduces the remaining degeneracy in the plane. We further demonstrate that, under an SKA1-Low-like uncorrelated thermal-noise model, noise predominantly produces short-lived fluctuations that are removed by a uniform persistence cut, leaving the topology of long-lived troughs and the gross Betti-curve morphology largely intact. These results establish persistence-based descriptors as a robust non-Gaussian probe of small-scale structure and heating during Cosmic Dawn, naturally complementing power-spectrum and wavelet-based analyses.

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