We characterise C*-irreducible regular C*-inclusions using a number of different conditions considered by different authors. In particular, we show that all C*-irreducible regular inclusions are modelled by outer Fell bundles over discrete groups with a simple unit fibre . In this case, we prove a bijection between intermediate C*-algebras and subgroups of . This extends the Galois correspondence for reduced crossed products by discrete group actions established by Cameron-Smith. We relate it to the Galois correspondences of Izumi and Mukohara for fixed-point algebras of actions of compact abelian groups, and the mixed inclusion of a fixed-point algebra in a reduced crossed product considered by Echterhoff-Rørdam. In addition, using a recent result of Geffen-Ursu, we show that the inclusion of a fixed-point subalgebra of an action of or for a square-free number is aperiodic if and only if detects ideals in . We apply this to give examples of C*-irreducible inclusions coming from Cuntz-Pimsner algebras, including crossed products by endomorphisms or transfer operators. In particular, we characterise when a core subalgebra of a graph C*-algebra is C*-irreducible. Lastly, we show that a general regular topologically graded C*-inclusion is aperiodic and has a unique pseudo-expectation provided detects ideals in all intermediate C*-algebras of . This partially answers a question by Pitts-Zarikian.

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