This paper proposes a novel composite boundary feedback control law that ensures input-to-state stability (ISS) for a coupled ODE-parabolic PDE system with time-varying coefficients in both subsystems. In controller design, we circumvent the need to directly solve coupled time-varying parabolic-hyperbolic kernel equations by employing an analytic pre-defined gain function and a time-varying Volterra kernel function to design the control law explicitly. In stability analysis, to address the simultaneous challenges of Dirichlet boundary disturbances and time-varying coefficients, we employ the square root of a time-varying positive definite matrix and a superlinear function to construct a nonquadratic Lyapunov function for the ODE and a generalized Lyapunov functional for the PDE, respectively, in the target system, thereby establishing the ISS in the -norm of the closed-loop system. Numerical simulations are presented to illustrate the effectiveness of the proposed control scheme.

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