In high-mobility doubly dispersive links, basis expansion models (BEMs) reduce channel dimensionality, yet unknown payload symbols generally contaminate conventional matched-pilot channel estimates. This paper establishes the exact conditions under which such estimates become payload-independent and derives a pilot, guard, and data-placement rule that guarantees these conditions. We prove a necessary-and-sufficient zero pilot–data interference (ZPDI) condition under which the matched-pilot least-squares (LS) solution coincides with the maximum-likelihood (ML) estimator for the reduced pilot statistic. When ZPDI holds, estimation requires a single precomputed projection. When it does not, the estimate contains a deterministic, channel-scaled payload bias that persists at high signal-to-noise ratio. A disjoint-support rule, independent of the selected basis, realizes ZPDI through pilot, guard, and data placement. We then specialize the framework to orthogonal time–frequency space (OTFS) and examine its structural and performance consequences. With the generalized complex-exponential BEM (GCE-BEM), the ZPDI estimator remains within about ~dB of the perfect channel state information benchmark in bit error rate at speeds up to 500~km/h.

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