In this paper, we study the existence of normalized solutions to the following -supercritical nonlinear Schrödinger equation with a periodic potential where , is prescribed, is a Lagrange multiplier, is -periodic in , exhibits a general mass supercritical growth at infinity, is a (nonempty) bounded open set with smooth boundary and is the characteristic function of . We prove the existence of normalized solutions for all sufficiently small. Moreover, if further has a mass-supercritical growth near the origin, then the existence result extends to every . The result is obtained through a combination of the monotonicity trick, minimax principle with Morse index information for constrained functionals and blow-up analysis.

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