A search for pair-produced vector-like -quarks in 139 fb of collisions recorded by the ATLAS detector at a centre-of-mass energy =13 TeV is presented. The search targets signal events where at least one -quark decays into a Higgs boson and a top quark, , with subsequent decays of the Higgs boson into a bottom quark-antiquark pair, , and the top quark into a light charged lepton, a neutrino and a bottom quark, , where . The decay products of boosted heavy resonances are reconstructed using variable-radius, reclustered jets, and a neural network is employed to discriminate signal from Standard Model background processes. A profile-likelihood fit to the effective mass distribution is performed, and no excess above the Standard Model prediction is observed. Exclusion limits at 95% confidence level are set on the -quark pair-production cross-section, corresponding to lower mass limits of 1.40 TeV in the SU(2) singlet representation, 1.56 TeV in the SU(2) doublet representation, and 1.66 TeV assuming the branching fraction of -quarks to to be 100%.

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